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 In contrast with mouse thymocytes, mouse ES cells comprise higher ranges of whole genomic H3K4me3 and have larger H3K4me3 occupancy at the promoter of the pluripotent gene Oct4 forty six In settlement with this, global decreases in H3K4me3 ranges happen during retinoic acid (RA)-induced differentiation of mouse ES cells 47 In addition, there are dynamic changes in H3K4me3 profiles at specific sets of genes throughout ES cell differentiation.
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